HGH Androchem (Human Growth Hormone) was first isolated from the hypothalamus in the 1950s. The area of medical application has not changed since then. Both then and now, HGH was prescribed for dwarfism, a disease in which the body does not produce enough growth hormone, which stops the process of bone and muscle growth.
In 1984, growth hormone extraction from the human hypothalamus had to be stopped following the deaths of people taking HGH. After careful research, it turned out that the cause of death was actually infected human growth hormone.
However, there was no shortage of substances, because in the meantime genetic tests allowed for the synthetic synthesis of the growth hormone. The world-famous pharmaceutical company “Lilly” has created a preparation called “Humatrope” – a synthetic hormone, identical to the human one.
Growth hormone is a natural polypeptide hormone consisting of 191 amino acids. It is formed in the anterior pituitary in response to stimuli such as intense stress, sleep, stress, and low blood sugar.
It has a positive effect on muscle growth, regeneration capacity, fat burning, joints, strength and age of cells. It is rightly called the “youth hormone”, as the level of growth hormone production regularly drops from the age of 20.
Within 10 years, it drops by 15%. In most 60-year-olds, the level of natural growth hormone production drops to 25%, which results in the loss of full physical and mental fitness. Therefore, more and more stars surrender to the so-called A “rejuvenating treatment” that involves injecting growth hormone.
Thanks to such treatment, muscle mass increases, vitality improves, physical and mental strength increases, sexual desire and desire for sex increase, the complexion is smoother, appearance and well-being improve. For athletes, however, the effects of growth hormone on muscle growth and fat loss are of greatest importance.
Growth hormone began to be used in bodybuilding circles in the early 1980s. The comparison of the figures of the Olympians of the late 70’s with the figures of the participants of the 198-1998 Olympics, the period when the use of growth hormone in bodybuilding was started, shows huge changes.
The bodybuilders of the early 1980s suddenly became heavier and taut, and their muscles were modeled, with better muscle density than their colleagues in the late 1970s. Current bodybuilding could no longer function without HGH.
It can be said that growth hormone is the most powerful anabolic hormone substance that leads to muscle growth and fat reduction. None of the anabolic steroids can equal the effectiveness of growth hormone.
Regardless of whether an advanced bodybuilder or a professional athlete, growth hormone has an equally positive anabolic effect on the body of each of them. Those who can use it properly are delighted with it, but those who do not have basic information about the effects of this preparation will be disappointed.
This is due to the fact that growth hormone is a hormone with a comprehensive action and is active on various levels, and therefore it is supported by the activity of other hormones.
While anabolic steroids are administered deeply intramuscularly, growth hormone is usually subcutaneously administered, ie with a thin insulin needle directly under the skin on the abdomen. This has the advantage that the substance penetrates the blood very quickly. Already after 10 minutes, elevated values of somatotropin are detected in the blood, which constantly increase until the maximum concentration is reached after 4-6 hours.
At the same time, however, the half-life of somatropin in the blood is 20-30 minutes, i.e. any amount of somatropin that has entered the blood as a result of the injection of growth hormone disappears by 50% after 20-30 minutes. The remaining part is accumulated in the blood and after 4-6 hours it reaches the maximum concentration of somatropin in the blood. The remaining 50% goes to the liver.
For a long time it was believed that the liver was the only place in the body where growth hormone stimulated IGF-1 binding. In the meantime, we already know that muscle cells also have growth hormone receptors and bind IGF-1 locally.
The condition, however, is, as in the case of liver cells, a sufficient supply of testosterone, insulin and thyroid hormone. The phenomenon is that IGF-1 produced in muscle cells acts as a factor of cell growth and division into local cells, both neighboring and own cells.
This means that IGF-1 produced in a cell causes not only the growth and division of that cell, but also of neighboring cells. On the other hand, steroids only cause a cell to grow, without dividing it.
Growth hormone also directly affects skeletal muscles and fat cells – it is associated with adipose tissue by a number of physiological processes. Fat cells are the primary target of growth hormone due to the fact that they are equipped with a large number of growth hormone receptors.
After injecting the hormone
Growth hormone molecules found in the bloodstream combine with molecules of fat cells to form a receptor-molecule complex. During this process, the growth hormone molecule tells the fat cell molecule that triglyceride is released.
The triglycerides contained in the fat cell are broken down into parts – free fatty acids (FFS) and glycerol (alcohol), and in a ratio of three FFS molecules to one glycerol molecule (FFS: GLICEROL 3: 1), secreted into the blood.
The result is a contraction of the fat cell. This mode of action of growth hormone occurs without the participation of IGF-1. After administration of growth hormone, the blood FFS to glycerol ratio is 14: 1. So it must be concluded that HGH not only breaks down fat but also blocks the growth of fat cells.
By reducing the amount of fat in the body, growth hormone prevents fat cells from taking over the fatty acids in the bloodstream from the fats you eat.
Long-term use of growth hormone also increases the resistance of fat cells to insulin. This means that growth hormone reduces the ability of fat cells to respond to insulin. As a result, insulin cannot transport glucose molecules from the bloodstream to fat cells to be deposited there as triglycerides.
Thus, growth hormone prevents insulin from depositing fat. This explains why the concomitant use of growth hormone and insulin does not lead to fat accumulation, while the administration of insulin alone is associated with significant fat gain.
During competition preparation or in the diet phase, it ensures high fat burning. At the same time, like no other hormone, it protects the existing mass from degeneration. In addition, it allows you to take insulin during competition, also during performances you can present the maximum volume of muscles.
Nowadays, there are no national or professional bodybuilders who do not take growth hormone during the diet phase. The same applies to the anabolic phase of ambitious athletes – growth hormone allows them to use extra insulin and provide large amounts of calories and protein without the risk of fat build-up.
Anabolic effects of HGH on muscles
The first step in muscle growth with growth hormone is to increase the volume of cells inside the muscles. This means that at the beginning much more water penetrates into the muscle cells, which increases their volume, and thus a place is prepared in the muscle cells for the protein deposited there later.
The initial increase in body weight from taking growth hormone is almost entirely due to an increase in body water. Increased sodium retention is at the root of changes in body water content. This explains why people using growth hormone experience more than average water retention at the start of treatment.
The most important thing then becomes calm, because the water supply is gradually lost in the next 2-3 weeks and real muscle growth appears in its place. Besides, the sizes of these stocks are still small compared to the size of the dose.
The so-called the proper effect of growth hormone on muscle growth begins after approx. 2-3 weeks of use, when elevated nitrogen values are detectable in the body. Since nitrogen binds proteins or amino acids, it is an excellent measure of the degree of anabolic processes in the body.
HGH has high sodium retention, which is caused by two mechanisms. Firstly, it is the anabolic effect of growth hormone, which causes a marked increase in the intracellular transport of amino acids and stimulates protein biosynthesis.
After administration of growth hormone, the content of amino acids in the blood drops rapidly as they are transported from the blood to the muscle cells. In muscle cells, growth hormone activates protein biosynthesis, i.e. the new amino acids are incorporated into contractile muscle proteins.
Protein-rich food is the basis here, because the anabolic effect of growth hormone is more effective the higher the protein intake.
HGH and anabolic steroids
Whoever decides to take growth hormone must also use steroids. The amount of IGF-1 produced in liver and muscle cells after HGH administration depends on the concentration of testosterone in the blood. For HGH, guided by IGF-1, to become fully effective, it must have sufficient testosterone available.
Of all the anabolic / androgenic steroids, Testosterone is the best. Since synthetic testosterone in injection is identical to natural testosterone, it creates the right conditions in the body for the optimal use of the properties of growth hormone.
If we suddenly increase the level of growth hormone in the body with an injection,
it is natural that he needs more testosterone.
The higher the growth hormone doses, the more Testosterone you need to supply. At 2-4 I.U. HGH per day is usually 700-1000mg of testosterone per week. Daily dose 5-8 I.U. HGH in the anabolic phase requires 1000-1500mg of Testosterone per week.
For over 8 I.U. HGH per day is needed in the anabolic phase of 1500-2000mg of testosterone per week. In the preparatory phase before the competition, it is customary to maintain a slightly lower dose level, most often 700-1000 mg of testosterone per week, because then the main goal is not maximum weight gain.
After providing the appropriate doses of HGH and Testosterone, other anabolic steroids can be added (according to the intended goals) – especially those that show good IGF-1 stimulation.
HGH and thyroid hormones
All manufacturers of growth hormone preparations indicate in the enclosed leaflet that while using growth hormone there is an increased need of the body for thyroid hormones. If this increased body requirement for thyroid hormones is not compensated, hypothyroidism may develop, reducing the effects of growth hormone.
The combination of growth hormone and thyroid hormone in the long term also contributes to better muscle building and increased fat burning, which has long been known in the circles of active bodybuilders.
The problem, however, is that high levels of growth hormone stimulate the hypothalamus to increase the secretion of the hormone somatostatin. Somatostatin is transported through the circulatory system to the pituitary gland and stops its own production of growth hormone and, unfortunately, also the thyroid stimulating hormone – TSH.
Thus, TSH is partially or completely blocked, which is designed to stimulate the thyroid gland to produce and release both the thyroid hormones T4 and T3. As a result, the thyroid gland produces less T4 and T3, which corresponds to classic hypothyroidism.
At the same time, the levels of T4 and T3 in the blood drop, and the body is deprived of enough thyroid hormones in the blood to be able to produce the maximum amount of IGF-1 in liver and muscle cells. Recall that in addition to testosterone and insulin, thyroid hormones are also necessary for the production of IGF-I after injection of growth hormone.
The best direct way to achieve a sufficiently high blood T3 concentration is to take the thyroid hormone T3. Regarding dosage, a dose of 25-50mcg T3 is sufficient. This is enough to sustain enough IGF-1 production.
When starting the treatment with growth hormone, or when it is used no more than 2 I.U. Thyroid hormone is not needed immediately per day, as it takes some time for endogenous TSH secretion to become apparently blocked.
After approx. 3 months or from a dose of 4 I.U. HGH daily, increasing the dose of T3 by about 25-50mcg per day should be considered. From now on, the period of T3 use is adjusted to the duration of the treatment with growth hormone.
Such moderate amounts of HGH should not lead to permanent hypothyroidism, on the contrary – temporary hypothyroidism caused by growth hormone is alleviated and the body functions remain undisturbed.
In the case of hypothyroidism, the body will certainly be helped by supplying it with the synthetic hormone that is necessary in this case.
Growth hormone and insulin
During the treatment with growth hormone, insulin plays a special role in the formation and regulation of IGF-1. In addition to testosterone and thyroid hormone, it is the third companion hormone that must necessarily be present in sufficient quantity to ensure maximum IGF-1 production.
Both liver and muscle cells that produce IGF-1 are doomed to insulin. In addition, insulin extends the life of IGF-I molecules in the bloodstream.
It is also important that insulin regulates the amount of growth hormone receptors in the liver. Too little insulin, i.e. an insulin deficit, leads to a loss of growth hormone receptors in the liver. Prolonged use of growth hormone in excessively high doses can lead to an insulin deficit such that the cells of the pancreas are unable to produce enough insulin.
Growth hormone puts a heavy strain on the insulin-producing Langerhans beta cells in the pancreas, causing insulin secretion to rise initially, then to cell damage and a reduction in insulin secretion.
A treatment with growth hormone for several months may lead to the degradation of growth hormone receptors in the liver tissue, with the consequence that some of the growth hormone taken is not absorbed by the liver and cannot be used to create IGF-1.
Persistent HGH administration usually results in hyperglycaemia, i.e. an increase in blood sugar, which is caused both by an insulin deficit and growth hormone-induced insulin resistance to various
organs.
Not only does this resistance interfere with optimal IGF-1 production, it can also lead to health problems in the long run. If insulin levels remain elevated for months or even years, this creates an opportunity for diabetic metabolism, i.e. the development of diabetes mellitus.
When it comes to the use of insulin, it is best to choose insulin with a short duration of action and avoid insulin with a medium or long duration of action. The most important rule to follow when using insulin is the need to be able to control the action of the hormone on sugar levels.
As you might guess, the simplest one is for short-acting insulin. Insulin with a short duration of action is closest to the physiological properties of the body. The insulin dose for bodybuilders should be 10-15 I.U. 2-3 times a day until breakfast, followed by an injection of growth hormone.
The second injection of insulin occurs post-workout in combination with fast-absorbing carbohydrates, and another injection of GH.
In exceptional cases, such as some professional bodybuilders, a third injection of 10 I.U. short-acting insulin with lunch. However, the reality shows a significant dose range, especially among professionals. The duration of insulin use usually depends on the length of the HGH treatment.
Many athletes use the 6 weeks on / 2 weeks off system, i.e. taking insulin for 6 weeks every day and 2 weeks off. This avoids pancreatic dysfunction and reduces the risk of subsequent diabetes. However, this is not the only way to receive. There are as many of them as schools and masters in bodybuilding.
Side effects
While it is commonly believed that bone cannot grow any more after puberty, the reality is different. While growth hormone experimentation seemed unlikely thirty years ago, it has become a matter of course today.
Professional bodybuilders with oversized jaws, a slightly “knotted” forehead and flared cheekbones are not uncommon these days. The occurrence of acromegaly is obviously dosed dependent. The higher the daily dose, the higher the risk of facial bone growth.
Since many professional and amateur bodybuilders use doses of 8-16 I.U almost all year round without major breaks. day, it is not surprising that their facial skeleton changes, which has become the norm in the meantime. The larger volume of the skull itself is also noticeable.
The biggest problem with regular use of growth hormone is the effect of HGH on blood sugar levels. Over time, hyperglycaemia, i.e. too high blood sugar levels, develops and leads to diabetic changes in the metabolism if no preventive measures are taken.
Growth hormone induces insulin resistance at certain cellular levels and, in addition, damages beta cells that produce insulin in the pancreas with prolonged use. All of this contributes to an insulin deficit in the body, resulting in a constant increase in blood sugar levels.
An unpleasant feeling when using growth hormone is numbness of the fingers and sometimes the entire hand. This effect causes increased intercellular water accumulation, and pressure on the nerves in the hand and forearm joint causes disturbances in the blood supply to the hand. The result is the inertia of the hand, felt especially by people sleeping on their side.
In the first 2-3 weeks of use, in many cases blood pressure increases and edema is formed, especially in the ankles and on the face. These phenomena disappear with further treatment. Problems with falling asleep and sudden sweating can occur if you have had your GH injection too late in the evening.
It cannot be ruled out that growth hormone also causes the growth of smooth muscles, i.e. the gut with the stomach and digestive system. A bloated stomach is often seen in professional bodybuilders, which may be the result of regular growth hormone injections.
Others believe that a bloated abdomen only occurs with a combination of growth hormone and insulin, while others believe it is the result of the extreme amounts of food provided during the growth phase. There is no clear evidence to confirm any of the above theses.
The fact is, however, that a protruding, bloated abdomen is not uncommon today among professional bodybuilders, which was not yet seen in the 1980s. So one may be tempted to argue that really high doses of insulin and growth hormone play a role here.
After all, growth hormone is a relatively safe and well-tolerated hormone, especially in daily doses of 2-6 I.U. HGH is non-toxic and is not harmful to the liver or kidneys.
Since it has no androgenic characteristics, there are also no steroid-specific side effects, such as
e as acne, hair loss, loss of sex drive, testicular atrophy, gynecomastia and aggressive behavior.
Dosage
The most important rule when using growth hormone is that the length of the treatment is more important than the dosage. This would mean that e.g. treatment with HGH 2 I.U. daily for 6 months will bring better results than with higher daily doses, e.g. 4-8 I.U. for 2 months.
In principle, it can be said that the minimum duration of treatment, especially in the muscle growth phase, cannot be less than 3 months. Even a period of 6-1 2 months would be better when using low to medium doses – 2-6 I.U. for day. The longer we apply HGH, the better the effect our body has.
While only water is stored in the beginning, the anabolic, muscle-building effects of growth hormone increase over time. This effect lasts for months and produces steady, solid muscle growth with a simultaneous, steady increase in strength.
The effective daily dose should be 2-6 I.U. The injection is made under the skin of the abdomen. People who start treatment should start with a dose of 2 I.U. and be financially ready for a 6-month treatment. Bodybuilders who have already treated with a dose of 2 I.U. may, in their second cycle, increase the dose to 4 I.U per day.
However, they will not need more than 6 I.U. per day. Ambitious national bodybuilders and professional athletes, of course, need more, but the condition is that both insulin and thyroid hormone levels are increased simultaneously.
Otherwise, you will experience unnecessary side effects. Admittedly, in bodybuilding you hear about professionals taking 32-36 I.U. HGH per day, however, it must be said that most of them are satisfied with a dose of 8-16 I.U. per day.
Regardless of the dosage you choose, you should inject growth hormone at least twice a day, as its half-life is several hours. Ideally, the first injection should be in the morning after breakfast and the next injection after training, immediately before the meal after training.
The daily dose is then divided in half. If, for example, someone applies 2 I.U. daily, it injects 2 x 1 I.U., who 4 I.U. is 2 I.U. in a single injection, etc. It is important to have a sufficient amount of carbohydrates and easily digestible proteins with meals.
It should be noted that HGH should be reached by those players who have already used all available means in various combinations in their careers, and they have already combined them with HGH.
People taking their first steps in doping, as well as intermediate people, should not reach for Growth hormone yet. And the dosing schedule should be planned with someone who has already had at least one treatment with HGH.
Putting down
With doses of 2-4 I.U, no skipping of doses is practiced. Only in the case of a dose of 6 I.U and more, a slow dose reduction is recommended. PCT is also planned for other measures used in the cycle. Androchem.
